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. 2021 Apr 20;12:645143. doi: 10.3389/fimmu.2021.645143

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Copyright © 2021 Caproni, Capone, Rossi, Santarlasci, Maggi, Mazzoni, Rossettini, Renzi, Quintarelli, Bianchi, Ninci, Lami, Calabrò, Cosmi, Annunziato and Liotta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PB Cytokine-producing T cells frequencies correlation with disease activity score and evaluation after gluten free diet in DH patients. (A) Correlation between disease activity score PDAI and frequencies of circulating CD4+ T cells producing TNFα (left panel) and L-17A (right panel) was calculated in 15 DH patients. (B) Frequencies of intracellular cytokines producing CD4+ T cells in fresh samples from PB were evaluated in 8 DH patients before and after 1 year of gluten free diet (GFD). Columns represent means ( ± SE) of the indicated cytokine. *p ≤ 0.05. (C) Frequencies of circulating CD4+ T cells producing TNFα (left panel) and IL-17A (right panel) in fresh samples from PB were evaluated before (To) and after 1 and 2 year of gluten free diet (GFD) in 5 DH patients. ( ± SE). *p ≤ 0.05 compared to the To evaluation.