Table 2.
Prognostic factors for OS, CSS and RFS of BC patients treated with RC in univariate and multivariate Cox regression analyses.
| Covariates | OS | CSS | RFS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||
| HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Age | 1.03 (1,1.06) | 0.094 | 1.01 (0.98,1.05) | 0.407 | 1.01 (0.98,1.04) | 0.551 | ||||||
| Sex | ||||||||||||
| Female | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Male | 0.89 (0.48,1.65) | 0.716 | 0.73 (0.39,1.36) | 0.321 | 0.8 (0.44,1.46) | 0.476 | ||||||
| BMI | 1.47 (0.88,2.45) | 0.140 | 1.02 (0.96,1.09) | 0.526 | 1.03 (0.96,1.09) | 0.427 | ||||||
| Smoking history | ||||||||||||
| No | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Yes | 2.1 (1.25,3.53) | 0.005* | 1.81 (1.0,3.29) | 0.050* | 3.46 (1.87,6.38) | < 0.001* | 3.28 (1.60,6.72) | 0.001* | 3.04 (1.75,5.28) | < 0.001* | 3.13 (1.63,5.98) | < 0.001* |
| ECOG-PS | ||||||||||||
| 0 | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| 1 | 0.5 (0.24,1.02) | 0.057 | 0.29 (0.11,0.74) | 0.010* | 0.44 (0.16,1.22) | 0.114 | 0.43 (0.2,0.92) | 0.030* | 0.54 (0.23,1.27) | 0.158 | ||
| 2 | 0.93 (0.44,1.99) | 0.857 | 0.76 (0.32,1.79) | 0.524 | 1.22 (0.44,3.41) | 0.701 | 0.88 (0.41,1.87) | 0.737 | ||||
| Diabetes | ||||||||||||
| No | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Yes | 0.67 (0.32,1.36) | 0.266 | 0.68 (0.32,1.47) | 0.326 | 0.85 (0.43,1.69) | 0.648 | ||||||
| Hypertension | ||||||||||||
| No | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Yes | 0.71 (0.35,1.45) | 0.354 | 0.74 (0.35,1.57) | 0.433 | 0.84 (0.42,1.65) | 0.610 | ||||||
| Chemotherapy | ||||||||||||
| No | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Yes | 0.47 (0.21,1.03) | 0.060 | 0.55 (0.25,1.24) | 0.150 | 0.59 (0.28,1.24) | 0.162 | ||||||
| ASA classification | ||||||||||||
| 1 | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| 2 | 1.16 (0.59,2.27) | 0.664 | 1.07 (0.52,2.18) | 0.855 | 1.13 (0.58,2.22) | 0.711 | ||||||
| 3 | 1.31 (0.56,3.11) | 0.533 | 1.32 (0.53,3.26) | 0.550 | 1.1 (0.46,2.65) | 0.834 | ||||||
| T-stage | ||||||||||||
| T1-T2 | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| T3-T4 | 2.25 (1.28,3.95) | 0.005* | 2.43 (1.30, 4.56) | 0.006* | 2.59 (1.43,4.68) | 0.002* | 3.99 (1.94, 8.18) | < 0.001* | 2.49 (1.41,4.37) | 0.002* | 3.88 (2.00, 7.55) | < 0.001* |
| Lymph node status | ||||||||||||
| Negative | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Positive | 1.76 (1.02,3.06) | 0.044* | 1.13 (0.60, 2.14) | 0.696 | 2.07 (1.16,3.7) | 0.014* | 1.39 (0.70, 2.77) | 0.350 | 1.85 (1.06,3.21) | 0.029* | 1.22 (0.64, 2.32) | 0.540 |
| Tumor grade | ||||||||||||
| Low | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| High | 2.19 (1.31,3.65) | 0.003* | 2.27 (1.28, 4.03) | 0.005* | 2.92 (1.65,5.2) | < 0.001* | 3.41 (1.71, 6.79) | 0.001* | 3 (1.76,5.12) | < 0.001* | 3.47 (1.87, 6.44) | < 0.001* |
| HGB | ||||||||||||
| <130 | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| ≥130 | 1.01 (0.99,1.02) | 0.331 | 1.19 (0.69,2.06) | 0.539 | 1.08 (0.65,1.8) | 0.763 | ||||||
| AAPR | ||||||||||||
| Low | 1 (reference) | 1 (reference) | 1 (reference) | |||||||||
| Medium | 0.54 (0.29,0.99) | 0.048* | 0.36 (0.17,0.77) | 0.008* | 0.52 (0.27,1) | 0.051 | 0.32 (0.13,0.74) | 0.008* | 0.52 (0.28,0.96) | 0.037* | 0.29 (0.13,0.63) | 0.002* |
| High | 0.24 (0.13,0.46) | < 0.001* | 0.21 (0.10,0.42) | < 0.001* | 0.21 (0.11,0.42) | < 0.001* | 0.18 (0.08,0.39) | < 0.001* | 0.21 (0.11,0.41) | < 0.001* | 0.17 (0.09,0.36) | < 0.001* |
*P < 0.05. OS, overall survival; CSS, cancer-specific survival; RFS, recurrence-free survival; BC, bladder cancer; RC, radical cystectomy; AAPR, albumin-to-alkaline phosphatase ratio; ECOG-PS, Performance Status of East Cooperative Oncology Group; ASA, American Society of Anesthesiologists; HGB, Hemoglobin.