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. 2021 Apr 20;12:623762. doi: 10.3389/fimmu.2021.623762

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Copyright © 2021 Song, Xu, Deng, Zhu, Fu, Chen, Lu, Xu, Song, Tang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A higher percentage of fibroblasts and/or fibrosis correlates with the abundance of CD8⁺ cells in OSA tumors. (A) Immunohistochemistry for CD8 expression in OSA tumor tissues. (B, C) H&E staining and Masson’s Trichrome staining of fibroblasts and/or fibrosis in OSA tumors. (D, E) Comparison of the density per high-power field of CD8⁺ cells, and H&E/Masson’s Trichrome staining score of fibroblasts and/or fibrosis in non-responders (PD) and responders (PR and SD). (F) Correlation analyses of the abundance of CD8⁺ cells and fibroblasts and/or fibrosis. PD, progressive disease; PR, partial response; SD, stable disease. The significance levels of the p-values are presented as *p < 0.05, **p < 0.01 or ns, not significant p ≥ 0.05.