Table 3.
Differences in cerebral physiology to bolus hyperosmolar therapy after intracranial hypertension.
| Physiologic variable | Difference with treatment responsiveness [median (IQR)] | Difference with treatment unresponsiveness [median (IQR)] | p-value |
|---|---|---|---|
| ICP, median (mmHg) | −1.66 (3.38) | +2.14 (2.910) | 0.0064 |
| ABP, median (mmHg) | −0.67 (4.19) | +0.31 (5.26) | 0.0126 |
| HR, median (bpm) | −1.00 (7.64) | +0.32 (6.38) | 0.8903 |
| PRx, median | −0.04 (0.22) | +0.02 (0.24) | 0.0063 |
| PAx, median | −0.06 (0.25) | +0.02 (0.25) | 0.0725 |
| wPRx, median | −0.03 (0.27) | −0.01 (0.25) | 0.2610 |
| RAC, median | −0.01 (0.17) | −0.03 (0.19) | 0.3672 |
| RAP, median | −0.01 (0.31) | +0.03 (0.11) | 0.0756 |
| AMP, median | −0.10 (0.40) | +0.16 (0.46) | 0.0795 |
| HRsd, median | −0.06 (0.83) | −0.03 (0.40) | 0.0408 |
| HRrmssd, median | −0.38 (5.06) | +0.04 (2.56) | 0.5242 |
| LHF Ratio, median | +0.05 (1.08) | +0.00 (0.29) | 0.8476 |
Analysis performed using generalized estimating equations. Bold variables are representative of statistical significance. ICP, intracranial pressure; ABP, arterial blood pressure; HR, heart rate; bpm, beats per minute; mmHg, millimeters of mercury; PRx, pressure reactivity index; PAx, pulse amplitude index; wPRx, wavelet-pressure reactivity; RAC, correlation coefficient between intracranial pressure pulse amplitude and cerebral perfusion pressure; RAP, correlation coefficient between intracranial pressure pulse amplitude and intracranial pressure; AMP, intracranial pressure pulse amplitude; HRsd, standard deviation of heart rate; HRrmssd, root mean square of successive differences of heart rate; LHF, low frequency-high frequency ratio.