Table 4.
Differences in cerebral physiology in relation to hyperosmolar therapy without intracranial hypertension.
| Physiologic variable | Prior to treatment [mean (SD)] | After treatment [mean (SD)] | p-value |
|---|---|---|---|
| ICP, median (mmHg) | 11.06 (4.96) | 12.81 (10.49) | <0.0001 |
| ABP, median (mmHg) | 77.78 (11.25) | 78.57 (11.07) | <0.0001 |
| HR, median (bpm) | 99.87 (29.35) | 97.22 (31.19) | <0.0001 |
| PRx, median | 0.09 (0.41) | 0.10 (0.40) | <0.0001 |
| PAx, median | −0.22 (0.37) | −0.24 (0.36) | 0.0005 |
| wPRx, median | 0.04 (0.35) | 0.03 (0.36) | <0.0001 |
| RAC, median | −0.35 (0.42) | −0.38 (0.40) | <0.0001 |
| RAP, median | 0.46 (0.39) | 0.48 (0.38) | <0.0001 |
| AMP, median | 1.21 (1.17) | 1.26 (1.15) | <0.0001 |
| HRsd, median | 3.11 (1.82) | 3.38 (2.39) | <0.0001 |
| HRrmssd, median | 18.75 (18.43) | 20.89 (19.46) | <0.0001 |
| LHF Ratio, median | 1.59 (1.56) | 2.95 (10.81) | <0.0001 |
Analysis performed using one-way repeated-measures analysis of variance. Bold variables are representative of statistical significance. ICP, intracranial pressure; ABP, arterial blood pressure; HR, heart rate; bpm, beats per minute; mmHg, millimeters of mercury; PRx, pressure reactivity index; PAx, pulse amplitude index; wPRx, wavelet-pressure reactivity; RAC, correlation coefficient between intracranial pressure pulse amplitude and cerebral perfusion pressure; RAP, correlation coefficient between intracranial pressure pulse amplitude and intracranial pressure; AMP, intracranial pressure pulse amplitude; HRsd, standard deviation of heart rate; HRrmssd, root mean square of successive differences of heart rate; LHF, low frequency-high frequency ratio.