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. 2021 Apr 20;9:632779. doi: 10.3389/fcell.2021.632779

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Copyright © 2021 Huang, Li, Ye, Zhang, Lin, Wu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IATL and cisplatin synergistically inhibit cells growth and induce apoptosis. (A,B) DU145 or PC-3 cells were treated with IATL or cisplatin alone or their combination at the indicated concentration for 24 h; cell viability was determined by an MTT assay. (C,D) Combination index (CI) values were calculated by the Calcusyn software, and a CI value of less than 1 indicates synergism. (E–H) DU145 or PC-3 cells were treated with IATL or cisplatin alone or their combination at the indicated concentration for 24 h; cell apoptosis rate was analyzed by flow cytometry. (I,J) DU145 or PC-3 cells were treated with IATL or cisplatin alone or their combination at the indicated concentration for 20 h; caspase-3 and caspase-9 activity were measured by an assay kit. *p < 0.05, **p < 0.01.