Table 2.

OSMR and LIFR variants and their association with plaque phenotypes.

Gene	Variant	NES	Alleles	EAF	Info	Phenotype	β (s.e.)	p
OSMR	rs13168867	−0.13	C/T	0.393	0.999	Calcification	0.036 (0.077)	0.637
						Collagen	−0.259 (0.095)	6.22 × 10−3
						Fat content	0.248 (0.088)	4.66 × 10−3
						Intraplaque hemorrhage	−0.014 (0.080)	0.862
						Smooth muscle cells	0.001 (0.011)	0.913
						Vessel density	−1.06 × 10−4 (0.004)	0.976
						Macrophages	0.004 (0.015)	0.809
LIFR	rs10491509	0.29	A/G	0.351	0.989	Calcification	0.046 (0.082)	0.577
						Collagen	0.134 (0.104)	0.194
						Fat content	0.086 (0.094)	0.363
						Intraplaque hemorrhage	0.071 (0.086)	0.414
						Smooth muscle cells	−0.003 (0.012)	0.840
						Vessel density	0.002 (0.004)	0.577
						Macrophages	0.015 (0.016)	0.354

For each variant, the association with plaque phenotypes is given. NES: the normalized effect size on expression; Alleles: the effect allele and the other allele, respectively; EAF: effect allele frequency in the Athero-Express Biobank; Info: estimated imputation score in the Athero-Express Biobank; β, effect size; s.e., standard error; p, p-value of association; Adj. p, Bonferroni adjusted p-value. Calcification and collagen were classified as no/minor vs. moderate/heavy, fat content as 10 vs. >10% fat of plaque area, intraplaque hemorrhage was classified as absent vs. present. Smooth muscle cells and macrophages were classified as Box-Cox transformed percentage of plaque area and vessel density as Box-Cox transformed number of vessels/hotspot. None of the p-values surpassed significance threshold (3.13 × 10⁻³).