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. 2021 Apr 20;12:667474. doi: 10.3389/fphar.2021.667474

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Copyright © 2021 Yamamura, Nayeem, Muramatsu, Nakamura and Sato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Down-regulation of VEGFR-3 expression and p-Akt levels by MAZ51. The effects of MAZ51 on VEGFR expression and its downstream signal pathway, Akt, were examined in human prostate cancer PC-3 cells by Western blotting. (A) Representative blots of VEGFR-3, p-Akt (Ser473), and total-Akt in the absence and presence of 1 and 3 μM MAZ51 for 48 h in PC-3 cells. (B–D) The expression levels of VEGFR-3 (B), p-Akt (C), and total-Akt (D) in the absence and presence of MAZ51 in PC-3 cells (n = 8). (E,F) Representative blots (E) and the expression levels (F) of VEGFR-1 in the absence and presence of MAZ51 in PC-3 cells (n = 4). (G,H) Representative blots (G) and the expression levels (H) of VEGFR-2 in the absence and presence of MAZ51 in PC-3 cells (n = 4). These expression levels were normalized by that of β-actin. Data are presented as means ± S.D. *p < 0.05, **p < 0.01 vs. 0 μM MAZ51 (Scheffé’s test following ANOVA).