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. 2021 Apr 20;12:643857. doi: 10.3389/fphar.2021.643857

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Copyright © 2021 Paraiso, Tran, Magana, Kundu, Choi, Maier, Bobe, Raber, Kioussi and Stevens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XN differentially modulates classical and alternative pathways of synthesis in WT vs. FXR^Liver−/− mice. Heatmaps of individual BA concentrations in the plasma (A), liver (B) and hippocampus (C) of HFD-fed WT and FXR^Liver−/− mice. *p < 0.05, **p < 0.01, ***p < 0.001 for effect of XN treatment (n = 7–10 per group). Abbreviations: chenodeoxycholic acid (CDCA), cholic acid (CA), deoxycholic acid (DCA), lithocholic acid (LCA), muricholic acid (MCA), nordeoxycholic acid (NDCA), taurochenodeoxycholic acid (TCDCA), taurocholic acid (TCA), tauromuricholic acid (T-MCA), taurodeoxycholic acid (TDCA), tauroursodeoxycholic acid (TUDCA).