TABLE 2.

Concentrations of XN and metabolites (IX, 8PN, DXN) in the plasma and liver of females vs. males HFD-fed WT and FXR^Liver−/− mice.

	Plasma (nM)
	Female WT XN	Male WT XN	Female FXRLiver−/− XN	Male FXRLiver−/− XN
XN	22.61 ± 4.4	16.94 ± 3.2	30.45 ± 5.3	14.65& ± 1.8
IX	16.0 ± 4.0	8.73& ± 2.0	13.55 ± 3.2	8.78 ± 1.6
DXN	1.90 ± 0.4	3.02 ± 1.2	1.36 ± 0.45	3.60 ± 1.89
	Liver (nmol/g)
	Female WT XN	Male WT XN	Female FXRLiver−/− XN	Male FXRLiver−/− XN
XN	0.28 ± 0.05	0.16& ± 0.03	0.23 ± 0.08	0.29& ± 0.05
IX	1.53 ± 0.35	0.68& ± 0.08	0.58## ± 0.09	0.65 ± 0.05
8PN	0.04 ± 0.01	0.05 ± 0.01	0.06 ± 0.03	0.13&,&& ± 0.04

Data displayed as mean ± SEM (n = 7–10 per group). ^# p < 0.05, ^## p < 0.01 for genotype comparison, ^& p < 0.05, ^&& p < 0.01 for gender comparison.