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. 2021 Apr 20;12:644387. doi: 10.3389/fphar.2021.644387

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Copyright © 2021 Zhao, Du, Tian, Kang, Li, Dai, Li, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) SEM images of the different polymers. (B) The changes in OC-B-BBR nanoparticle size in pH 7.4 medium. (C) The changes in surface charges and PDI (D) In vitro drug release profiles of berberine. The OC-B-BBR micelle was incubated in pH = 7.4 buffer without H₂O₂ (black dot), 10 μM H₂O₂ (red square), and 1 mM H₂O₂ (wine square), as measured through HPLC.