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. 2021 Apr 20;9:619444. doi: 10.3389/fcell.2021.619444

FIGURE 6.

FIGURE 6

hnRNPA2B1 inhibition promotes re-endothelialization and reduces neointima formation following carotid injury. (A) Immunofluorescence staining shows hnRNPA2B1 (green) expression and localization in the arteries post-injury. (B) Levels of hnRNPA2B1 expression were determined in uninjured rat carotid arteries and at different times after left carotid arterial balloon injury by western blotting. *P < 0.05, **P < 0.01 vs. Sham group. (C) Representative images of Evan’s blue staining of carotid arteries from rats treated with control shRNA (sh-Ctrl), hnRNPA2B1 shRNA (sh-hnRNPA2B1) carrying lentivirus, sh-hnRNPA2B1 and Lenti-miR-185, or Lenti-miR-185 at day 7 after balloon injury. (D) Representative images of hematoxylin and eosin-stained paraffin sections of carotid arteries from rats treated with control shRNA (sh-Ctrl), hnRNPA2B1 shRNA (sh-hnRNPA2B1) carrying lentivirus, sh-hnRNPA2B1 and Lenti-miR-185, or Lenti-miR-185 at day 14 after balloon injury. Arrows indicate the internal elastic lamina. Quantifications of neointimal formation as intima/media area ratio are shown. *P < 0.05.