Table.

Number and rate of overdose deaths involving opioids, by race/ethnicity and sex, for adults aged 45-64, CDC WONDER, United States, 2018^a

Characteristics	Natural and semisynthetic opioidsb			Heroine			Synthetic opioidsf			Methadoneg
	Deaths, no.	Ratec	P valued	Deaths, no.	Ratec	P valued	Deaths, no.	Ratec	P valued	Deaths, no.	Ratec	P valued
Male
Non-Hispanic White	2410	8.7	<.001	2349	8.5	<.001	4691	17.0	<.001	551	2.0	.001
Non-Hispanic Black	334	7.0		841	17.7		1711	36.0		109	2.3
Hispanic/Latino	221	3.7		503	8.5		667	11.3		80	1.4
Non-Hispanic White vs non-Hispanic Black	—	—	<.001	—	—	<.001	—	—	<.001	—	—	.18
Non-Hispanic White vs Hispanic/Latino	—	—	<.001	—	—	>.99	—	—	<.001	—	—	.001
Non-Hispanic Black vs Hispanic/Latino	—	—	<.001	—	—	<.001	—	—	<.001	—	—	<.001
Female
Non-Hispanic White	2245	7.9	<.001	798	2.8	<.001	2162	7.6	<.001	487	1.7	<.001
Non-Hispanic Black	226	4.1		300	5.4		616	11.2		84	1.5
Hispanic/Latino	124	2.1		101	1.7		137	2.3		57	1.0
Non-Hispanic White vs non-Hispanic Black	—	—	<.001	—	—	<.001	—	—	<.001	—	—	.32
Non-Hispanic White vs Hispanic/Latina	—	—	<.001	—	—	<.001	—	—	<.001	—	—	<.001
Non-Hispanic Black vs Hispanic/Latina	—	—	<.001	—	—	<.001	—	—	<.001	—	—	.01

Abbreviations: CDC, Centers for Disease Control and Prevention; WONDER, Wide-ranging ONline Data for Epidemiologic Research.

^aData source: CDC Wonder.¹⁹ Deaths without a known race or Hispanic origin were excluded from the stratified analyses, including the population counts used to calculate mortality rates.

^bNatural opioids include drugs such as morphine and codeine, and semisynthetic opioids include drugs such as oxycodone, hydrocodone, hydromorphone, and oxymorphone.

^cThe rate is per 100 000 population.

^d P values are for overall Pearson χ² tests and post hoc tests with Bonferroni corrections to compare differences by race/ethnicity. P < .05 was considered significant.

^eHeroin is an illicit opioid synthesized from morphine.

^fSynthetic opioids (excluding methadone) include drugs such as fentanyl, fentanyl analogues, and tramadol.

^gMethadone is a synthetic opioid commonly prescribed for the treatment of opioid use disorder.