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. 2021 Apr 20;12:677757. doi: 10.3389/fphar.2021.677757

FIGURE 1.

FIGURE 1

HDAC8 selective inhibitor reduces isoproterenol-induced cardiac hypertrophy in mice (A) Representative images of hearts from sham, isoproterenol (ISP), and ISP + PCI34051 (30 mg/kg/day) mice treated for 5 days (B) Heart weight to body weight (HW/BW) ratios (n = 8). ***p < 0.001; ##p < 0.01 (C) Heart weight to tibia length (HW/TL) ratios (n = 8). ***p < 0.001; ###p < 0.001 (D) H&E staining, representative images of heart tissues from sham, ISP, and ISP + PCI34051 (30 mg/kg/day) mice treated for 5 days (n = 8). Scale bar = 50 μm (E) Quantification of cardiomyocyte size cross-sectional area of samples described in (D). ***p < 0.001; ###p < 0.001 (F) Representative M-mode echocardiograms after 5 days infusion of isoproterenol. PCI34051 was injected daily at 30 mg/kg/day for 5 days (G–H) Quantification of thickness of the left ventricular septum (IVSd) and posterior wall thickness (LVPWd) (n = 8). ***p < 0.001; ##p < 0.01 and ###p < 0.001. Data are presented as mean ± S.E. Statistics: one-way ANOVA followed by Bonferroni post hoc tests.