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Proposed role of HDAC8 in cardiac hypertrophy and fibrosis. Beta-adrenergic agonist isoproterenol increases the expression of HDAC8. Higher levels of HDAC8 induce p38 MAPK phosphorylation and increase the expression of cardiac hypertrophic markers ANP and BNP. PCI34051, a selective inhibitor of HDAC8, retards cardiac hypertrophy and fibrosis by inhibiting p38 MAPK activity.
