Table 2.
Monoamine levels and their metabolites (ng/g) after acute oral treatment with PNEO.
| Control | PNEO (5 mg/kg) | PNEO (10 mg/kg) | PNEO (50 mg/kg) | |
|---|---|---|---|---|
| DA | 158.6 ± 16.4 | 148.5 ± 15.6 | 150.6 ± 18.2 | 143.8 ± 25.2 |
| DOPAC | 216.5 ± 24.6 | 220.8 ± 25.5 | 214 ± 26.6 | 210.4 ± 29.6 |
| HVA | 322 ± 32.8 | 308.6 ± 32.8 | 302.5 ± 30.8 | 299 ± 32.6 |
| 5-HT | 184.4 ± 22.5 | 170.3 ± 18.6 | 162 ± 14.8 | 158 ± 22.4 |
| 5-HIAA | 145.8 ± 16.3 | 139 ± 16.5 | 136.5 ± 18.2 | 132.8 ± 20.6 |
The animal were treated with vehicle (control), PNEO (5, 10 and 50 mg/kg, p.o.). Data are represented as mean ± SEM (n = 6) and the values obtained by comparison with control group using one-way ANOVA followed by Dunnett's test. DA- Dopamine; DOPAC-3, 4-dihydroxyphenylacetic acid; HVA- Homovanillic acid; 5-HT- Serotonin; 5-HIAA-5-hydroxyindoleacetic acid.