Figure 1.

Overall structure of CD146 D4-D5 in complex with AA98 Fab

(A) Ribbon diagrams of CD146 D4-D5 in complex with AA98 Fab. CD146 D4 is shown in light pink, whereas D5 is shown in hot pink. The AA98 Fab light and heavy chains are shown in pale cyan and light blue, respectively. Glycans are drawn in stick representation with red oxygens and green carbons.

(B) Superposition of AA98 Fab-bound CD146 D4-D5 with D1-D2 of CD166 (5A2F) and D3-D4 of DCC (3LAF). The superposition is on CD146 D5. CD146 D4 is shown in light pink, whereas D5 is shown in hot pink. CD166 D1-D2 is shown in green, and DCC D3-D4 is shown in marine. The angle of 120° between the Fab-bound CD146 D4 and D5 is distinctively different from those in CD166 and DCC.

See also Figures S1–S3.