Prediabetes is defined as a condition of abnormal glucose metabolism, characterised by plasma glucose above normal range but not as high as required for the diagnosis of diabetes mellitus.

Prediabetes is recognised as an important metabolic state predisposing to a higher probability of future progression to diabetes mellitus and to an increased risk of different micro- and macrovascular complications.

The recently proposed sub-phenotyping of individuals at increased risk of type 2 diabetes mellitus offers the opportunity for improved screening, prevention, and treatment algorithms.

This novel clustering should enable more efficient and cost-effective strategies aimed at decreasing the disease burden associated with prediabetes.