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. 2021 Mar 26;3(2):fcab053. doi: 10.1093/braincomms/fcab053

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Manipulation of Ldh leads to exacerbation of climbing defects. (A) Plot of Performance index for a negative geotaxis assay of flies expressing Aß (Aß+) alone compared to flies expressing Aß and Ldh (Aß Ldh+), and their un-induced controls (Aß− and Aß Ldh−). Genotypes: UAS-Aß/UAS-Ldh; elav GS, UAS-Aß; elavGS. Aß UAS Ldh was not significantly different to Aß alone (P = 0.139 by ordinal logistics regression). (B) Plot of Performance index for a climbing assay of flies expressing Aß (Aß+) alone compared to flies expressing Aß and Ldh RNAi (Aß Ldh RNAi +), and their un-induced controls (Aß− and Aß Ldh RNAi−). Genotypes: UAS-Aß/UAS-Ldh RNAi; elav GS, UAS-Aß; elavGS. Aß Ldh RNAi genotype was significantly worse than Aß alone (P = 0.00552 by ordinal logistics regression). Note experiments were run in parallel with Aß+ and Aß− curves in Fig. 3a, but depicted separately for clarity.