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. 2021 Mar 26;296:100591. doi: 10.1016/j.jbc.2021.100591

Figure 11.

Figure 11

The surface-exposed lysine (Lys) and arginine (Arg) residues of collagen IV hexamers of α345 (top) and α121 (bottom) GBM scaffolds that can be adducted by glucose and glucose-derived reactive carbonyl products in diabetes.Top panel: The 3D structure of α345 hexamer is shown in three different projections rotated by 120° about the vertical axis. The labels indicate individual α3, α4, and α5 NC1 domains within the hexamer structure and locations of EA and EB hypoepitopes. The surface-exposed Lys and Arg side chains are shown in red and blue colors, respectively. Bottom panel: the 3D structure of α121 hexamer in two projections (120° rotation about the vertical axis) showing the location of the surface-exposed Lys and Arg side chains using the same color coding as in the top panel. GBM, glomerular basement membrane.