FIGURE 4.

Effects of CENDE on the expression of M2 macrophage markers and key protein expression. A‐E, Detection of M2 macrophage marker expression (n = 5): The expression of M2 macrophage markers was significantly increased in the THP‐1‐pcDNA3.1 group, which was significantly different from the THP‐1‐Con group. Meanwhile, the expression in the THP‐1‐shRNA group was lower than that of THP‐1‐Con group. Comparison between groups, *P <.05; **P <.01. F‐I, Effects of CRNDE on JAK‐STAT6 and AKT1 signal expression (n = 3): The expression of JAK1, STAT6, p‐STAT6, AKT1 and p‐AKT1 in the THP‐1‐pcDNA3.1 group was significantly higher than that of the THP‐1‐Con group. Meanwhile, the expression level in the THP‐1‐shRNA group was lower than that of the THP‐1‐Con group. Comparison between groups, *P <.05; **P <.01