TABLE 1.
Clinical characteristics of 24 newly diagnosed POEMS syndrome patients
| Clinical characteristics |
Patients with baseline serum and healthy control(%) (N = 24) |
|---|---|
| Demographic characteristics | |
| Age > 50 years | 33.3 |
| Male | 58.4 |
| POEMS syndrome‐related characteristics | |
| Polyneuropathy (ONLS > 4) | 20.8 |
| Organomegaly | |
| Hepatomegaly | 33.3 |
| Splenomegaly | 54.2 |
| Lymphadenopathy | |
| Endocrinopathy | 29.2 |
| Diabetes | 8.3 |
| Hypothyroidism | 75.0 |
| Monoclonal gammopathy | |
| IgA type heavy chain | 54.2 |
| SPE > 5 g/L | 12.4 |
| BMPC > 10% | 0.0 |
| Skin lesions | |
| Pigmentation | 91.6 |
| Angioma | 58.3 |
| Extravascular volume overload | |
| Peripheral oedema | 75.0 |
| Ascites | 41.7 |
| Pleural effusion | 37.5 |
| Castleman disease |
66.7 (N = 3) a |
| Papilloedema |
12.5 (N = 16) b |
| Osteosclerosis | 37.5 |
| Polycythemia | 16.7 |
| Thrombocytosis | 20.8 |
| Hypoalbuminemia (Alb < 30g/L) | 8.3 |
| Renal dysfunctione GFR < 30 ml/min/ 1.73m2 | 4.2 |
| 24h urinary protein > 1g | 4.2 |
| Risk stratification | |
| Low risk | 54.2 |
| Medium risk | 33.3 |
| High risk | 12.5 |
| Initial treatment | |
| ASCT | 20.8 |
| MDex | 4.2 |
| LDex | 25 |
| BDex | 50 |
a
A total of 3 out of 24 patients underwent lymph node biopsy and 2 patients were with Castleman disease.
b
A total of 16 out of 24 patients underwent ophthalmoscope examination and 2 patients were with papilloedema.