FIGURE 2.

ExoDiff, and not ExoPr0, reduced infarct size in in vivo model of ischaemia/reperfusion injury. Wild‐type mice were injected intravenously with the indicated numbers of ExoDiff, ExoPr0 or vehicle (PBS), 5 min prior to regional myocardial ischaemia. (A) Following 40 min ligation of the left anterior descending artery and 2 h reperfusion, the hearts were excised, stained with Evan's Blue and TTC (representative slices are shown). (B) The ischaemic risk area, as a percentage of the left ventricle (LV) area, was similar between all groups. (C) Infarct size as a percentage risk area. The data are shown as mean ±SEM. Each dot represents one mouse heart. *P <.05; **P <.01; ***P <.001, between indicated groups