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SFN activates cardiac Nrf2 partially through enhancing the acetylation of histone H3 in the Nrf2 promoter. A, The expression of HDAC2, 3 and 5 was examined by western blot. B, The total activity of HDAC was detected by HDAC activity kit. C, Western blot was performed to examine the expression of Ac‐H3 and Ac‐H4. D, ChIP assay was used to detect the Ac‐H3 enrichment in Nrf2 promoter region. Data were presented as the mean ± SD (n = 5‐7). *P < .05 vs control; # P < .05 vs Ang II
