Table 3.

Types of variants in β-thalassemia.

Gene	Variant type	Effect
β-globin gene	Transcriptional variants	β+ or β++
	Primary RNA transcript processing	β0, β+, or β++
	3’ UTR or poly-A site	β+
	Translation
	Initiation codon	β0
	Premature termination codon	β0

Abbreviation: UTR, untranslated region.