. 2021 May 3;4(5):e216831. doi: 10.1001/jamanetworkopen.2021.6831

Table 3. Association Between Infant Rapid Growth and Puberty Onset.

Growth metric by age	Participants with puberty onset, No./total No. (%)^a	Unadjusted		Adjusted^b
Growth metric by age	Participants with puberty onset, No./total No. (%)^a	HR (95% CI)	P value	HR (95% CI)	P value
Rapid weight gain
Birth to 3 mo
No	83/113 (73.5)	1 [Reference]	NA	1 [Reference]	NA
Yes	118/133 (88.7)	1.37 (1.03-1.81)	.03	1.39 (1.02-1.91)	.04
Birth to 6 mo
No	75/96 (78.1)	1 [Reference]	NA	1 [Reference]	NA
Yes	129/153 (84.3)	1.15 (0.86-1.53)	.34	1.10 (0.79-1.52)	.58
6 to 12 mo
No	178/217 (82.0)	1 [Reference]	NA	1 [Reference]	NA
Yes	22/26 (84.6)	1.08 (0.69-1.69)	.73	1.01 (0.63-1.62)	.98
12 to 24 mo
No	193/232 (83.2)	1 [Reference]	NA	1 [Reference]	NA
Yes	15/19 (78.9)	0.99 (0.58-1.67)	.97	0.98 (0.55-1.75)	.94
Birth to 24 mo
No	115/145 (79.3)	1 [Reference]	NA	1 [Reference]	NA
Yes	95/109 (87.2)	1.33 (1.02-1.75)	.04	1.40 (1.01-1.93)	.04
Rapid length gain
Birth to 3 mo
No	159/196 (81.1)	1 [Reference]	NA	1 [Reference]	NA
Yes	41/49 (83.7)	1.10 (0.78-1.55)	.58	1.18 (0.81-1.73)	.39
Birth to 6 mo
No	164/199 (82.4)	1 [Reference]	NA	1 [Reference]	NA
Yes	40/48 (83.3)	1.09 (0.77-1.54)	.63	1.06 (0.72-1.55)	.78
6 to 12 mo
No	132/164 (80.5)	1 [Reference]	NA	1 [Reference]	NA
Yes	68/79 (86.1)	1.00 (0.74-1.34)	.97	1.05 (0.76-1.45)	.76
12 to 24 mo
No	187/226 (82.7)	1 [Reference]	NA	1 [Reference]	NA
Yes	23/27 (85.2)	1.10 (0.71-1.69)	.67	1.05 (0.66-1.68)	.83
Birth to 24 mo
No	168/200 (84.0)	1 [Reference]	NA	1 [Reference]	NA
Yes	43/53 (81.1)	1.02 (0.73-1.43)	.91	1.01 (0.69-1.48)	.95

Abbreviations: HR, hazard ratio; NA, not applicable.

^{^a}

Denominators may differ owing to missing values.

^{^b}

Adjusted by small for gestational age, parental age, parental occupation, parental educational attainment, parity, maternal age at menarche, maternal BMI, household wealth index, and randomized prenatal supplement regimens.