TABLE 4.

Results of the three regression analyses with ANC as outcome.

Variable	Model 1		Model 2		Model 3
	Estimates	p	Estimates	p	Estimates	p
Clozapine concentration	−1.410	0.009	0.540	0.585	0.060	0.950
Norclozapine concentration	1.770	0.049	−1.450	0.385	−0.570	0.738
Daily dose	0.000	0.887	0.000	0.931	0.000	0.948
Gender [male]	0.030	0.886	0.040	0.829	0.080	0.626
Days between clozapine/ANC measurements	−0.010	0.113	−0.010	0.124	−0.010	0.105
Age	0.120	0.001	0.110	0.001	0.120	0.001
Age squared	−0.001	0.004	−0.001	0.004	−0.001	0.004
Time on clozapine	−0.001	0.036	−0.150	0.044	−0.001	0.020
Time between dose and sample	−0.050	0.105	0.060	0.080	−0.050	0.122
Ratio			−0.690	0.021	−0.540	0.035
rs2472297_T (clozapine)					−0.130	0.324
rs61750900_T (norclozapine + ratio)					−0.410	0.048
rs2011425_G (norclozapine)					0.450	0.026
rs1126545_T (ratio)					0.330	0.039

Bold highlight indicates statistically significant effect sizes (p < 0.05).