Table 4.

Comparison of the percentage (%) of mutational types for all (large and small) colonies produced in the mouse lymphoma cells treated with WLE of 4.5 and 5 mg ml⁻¹ and WLD of 8 mg ml^{−1 a}

Chromosome mutations	Controlb	WLE		WLD (8 mg ml−1)
		(4.5 mg ml−1)	(5 mg ml−1)
Non-LOH	36.0	3.3	4.0	11.9
Tk only	9.0	26.0	17.4	12.9
Tk→D11Mit42	17.0	45.6	51.2	53.7
Tk→D11Mit36	13.0	8.2	9.0	5.4
Tk→D11Mit20	5.0	2.1	6.9	4.3
Tk→D11Mit74	19.0	14.8	11.6	11.9

^aThe data are the weighted sum of percentages of large and small mutant colonies (Table 2), based on the proportion of small colony mutants (61% for WLE 4.5 mg ml⁻¹ treatment, 62% for WLE 5 mg ml⁻¹ treatment, and 47% for WLD 8 mg ml⁻¹ treatment). For the mutational spectra, all treatment groups were significantly different from the control (p < 0.0001) and there was a significant difference between WLE 4.5 mg ml⁻¹ and WLD treatment (p = 0.029). There was no significant difference between two WLE treatment groups (p = 0.373) or between WLE 5 mg ml⁻¹ and WLD treatment (p = 0.258).

^bThe data for the negative control are from the literature.²⁸