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. 2020 May 21;106(5):1433–1442. doi: 10.3324/haematol.2019.226852

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Figure 3. — Representative reverse-phase high performance liquid chromatography profile of the separation of hemoglobins in IVS2-745/β0 heterozygous sample treated with 2'-MOE-SSO 91. (A) Presence of α-heme aggregates and low levels of adult hemoglobin (HbA) detected in untreated cells from P1. (B) After treatment with 2'-MOE-SSO 91 the production of HbA was increased 11-fold and α-heme aggregates were reduced 2-fold. Fetal and HbA2 levels were unaltered. (C) Percentage of α-heme aggregates detected by reverse-phase high performance liquid chromatography in treated samples. All statistics (ANOVA/Kruskal-Wallis) are compared to scramble control. *P<0.1; **P<0.01; ***P<0.001; ****P<0.0001.