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Comparison of the efficacy of adult hemoglobin production between 2'-MOE-SSO 91 and lentiviral transduction in IVS2-745/b0 heterozygous sample. Percentage of adult hemoglobin (HbA) detected by reverse-phase high performance liquid chromatography in control and after treatment. Vector copy number determined via quatitative polymerase chain reaction. All statistical comparisons (ANOVA/Kruskal-Wallis) are tested against scramble control; n=3. ns=not significant, **P<0.01, ****P<0.0001.
