Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 21;106(5):1433–1442. doi: 10.3324/haematol.2019.226852

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PMC Copyright notice

Figure 8. — 2'-MOE-SSO 91 can rebalance the ratio of hemoglobins and produce enough functional adult hemoglobin to prevent sickling. (A) Percentage of adult hemoglobin (HbA), sickle Hb (HbS) and fetal Hb (HbF) chains detected by reverse-phase high performance liquid chromatography analysis in control-untreated, scramble- treated and oligo 91-treated specimens, at same dose of 50 mM, n=3. (B) In vitro sickling assay. IVS2-745/β-S cells were treated with scramble or oligo 91, then exposed to hypoxia. Barbed cells with long polymers of pointy sickle chains are indicated by yellow arrows.