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. 2021 Apr 29;218(6):e20200560. doi: 10.1084/jem.20200560

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© 2021 Higa et al.

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Figure 1. — HSPC-specific Cebpa knockout causes expansion of MPPs. (A–F) Hematopoietic characterization of Cebpa^+/+ and Cebpa^Δ/Δ mice 7 d after deletion. (A) Schematic to achieve traceable, tamoxifen-inducible, HSPC-specific knockout of Cebpa. (B) BM cellularity from one femur and one tibia per mouse. (C) HSPC frequency. (D) Committed progenitor frequency. (E) Mature cell frequency. (F) Complete blood count. CLP, common lymphoid progenitor; LT, long-term; ST, short-term. Data are from three separate experiments with n = 3 per group (n = 9 per genotype), presented as mean ± SD, and analyzed by unpaired Mann–Whitney U test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.