ChiCTR1800014553.

Study name	Comparative study of nasal high‐flow oxygen therapy and noninvasive positive pressure ventilation for moderate AECOPD: randomized open non‐inferiority trial
Methods	RCT, parallel‐group design
Participants	Total number of participants: 86 Setting: China Inclusion criteria: AECOPD; blood gas analysis pH 7.25‐7.35, PaCO2 > 50 mmHg Exclusion criteria: age < 18; no informed consent obtained; severe respiratory failure requiring tracheal intubation; NPPV contraindications; patients with short‐term prognosis; other organ failure; tracheotomy
Interventions	Intervention group (HFNC) Control group (NPPV)
Outcomes	All outcomes measured: arterial blood gas, respiratory rate, blood pressure, daily treatment time; parameter setting of NPPV and HFNC; change and time of respiratory support; intubation; time to intubation; dyspnoea score; comfort score; facial skin breakage; number of daily nursing interventions; respiratory and extrapulmonary complications; ICU length of stay; hospital length of stay; discharge outcome (death, improved) Outcomes relevant to this review: arterial blood gas, respiratory rate, intubation; dyspnoea score; comfort score; respiratory and extrapulmonary complications; ICU length of stay; hospital length of stay; mortality
Starting date	21 January 2018
Contact information	Dingyu Tan, 32494845@qq.com. Bingyu Ling
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