ChiCTR1900020826.

Study name	A multicenter randomized controlled clinical trial for standardized respiratory support treatment for acute severe virus pneumonia
Methods	RCT, parallel‐group design. Multicentre study
Participants	Estimated number of participants: 160 Setting: China Inclusion criteria: age > 18 years; acute viral pneumonia Exclusion criteria: indication for intubation and MV; received MV; hypercapnia; acute attack of bronchial asthma; acute exacerbation of COPD or other chronic lung diseases; cardiogenic pulmonary oedema; severe neutropenia; haemodynamic instability; GCS <= 12; contraindications to NIV; facial or nasal deformities, nasal deformities; requires airway protection; tracheotomy; refuses endotracheal intubation; pregnancy
Interventions	Intervention group (HFNC) Control group (NIV)
Outcomes	All outcomes reported: intubation rate; time to intubation Outcomes relevant to this review: intubation rate
Starting date	20 January 2019
Contact information	Liu Xiaoqing, lxq1118@126.com. Xi Yin, xiyin86@163.com
Notes