ISRCTN16912075.

Study name	In adult patients with known or suspected COVID‐19, does the use of continuous positive airway pressure (CPAP) or high‐flow nasal oxygen (HFNO), compared with standard care reduce mortality or need for tracheal intubation?
Methods	RCT, parallel‐group design. Single‐centre study
Participants	Estimated number of participants: 4002 Setting: ICU, UK Inclusion criteria: age >= 18; suspected or proven COVID‐19; FiO2 >= 40% with SpO2 < 94%; plan for intubation Exclusion criteria: planned intubation and MV within 1 hour; known pregnancy; contraindication to CPAP or HFNC; decision not to intubate due to ceiling of care; withdrawal of care anticipated; equipment for both CPAP and HFNC not available
Interventions	Intervention group (HFNC) Control group 1 (NIV): CPAP Control group 2 (standard oxygen therapy)
Outcomes	All outcomes reported: composite outcome comprising tracheal intubation or mortality within 30 days; intubation rate; time to intubation; time to death; mortality in critical care; hospital mortality; mortality at 30 days; ICU length of stay; hospital length of stay Outcomes relevant to this review: intubation rate; hospital mortality; ICU length of stay; hospital length of stay
Starting date	02 April 2020
Contact information	Keith Couper, k.couper@warwick.ac.uk.
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