NCT01702779.

Study name	Nasal humidified high‐flow oxygen during weaning from mechanical ventilation: ultrasonography study (HiFloLUS)
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 80 Setting: ICU, France Inclusion criteria: adult patients ventilated > 48 hours, stable respiratory and haemodynamic conditions for SBT, consent of participants, arterial line Exclusion criteria: COPD, laryngeal dyspnoea, tracheostomy, arrhythmia, no echogenicity, paraplegia > T8
Interventions	Intervention group (HFNC): Optiflow Control group (standard oxygen therapy)
Outcomes	All outcomes reported: variations in lung ultrasound score; lung ultrasound score; rate of post‐extubation distress; EIT, epithelial and endothelial biomarkers Outcomes relevant to this review: rate of post‐extubation distress
Starting date	August 2011
Contact information	Patrick Lacarin, University Hospital, Clermont‐Ferrand, placarin@chu‐clermonetferrand.fr
Notes	ClinicalTrials.gov identifier: NCT01702779