NCT03133520.

Study name	Effectiveness of high‐flow oxygen therapy in patients with hematologic malignancy acute hypoxemic respiratory failure
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 50 Setting: Turkey Inclusion criteria: immunosuppression; haematological malignancy; PaO2/FiO2 < 300 mmHg, or PaCO2 ≤ 45 mmHg, or SaO2 < 92 %; respiratory rate > 22 breaths/min Exclusion criteria: refusal of study participation; pregnancy or breastfeeding; hypercapnia with formal indication for NIV; treating physician decided NIV or invasive MV; haemodynamic instability; need for vasopressors; confusion or disorientation
Interventions	Intervention group (HFNC) Control group (standard oxygen therapy): nasal cannula or mask to achieve SpO2 ≥ 95%
Outcomes	All outcomes measured: 28‐day mortality; patient comfort Outcomes relevant to review: 28‐day mortality; patient comfort
Starting date	28 April 2017
Contact information	Kursat Gundogan, TC Erciyes University
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