NCT03171935.

Study name	Wean early with high‐flow nasal cannula oxygenation versus noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multicenter, randomized, controlled trial (the WHEN study)
Methods	RCT, parallel‐group design. Multicentre study
Participants	Estimated number of participants: 270 Setting: ICU, China Inclusion criteria: endotracheal intubation; PaO2 < 60 mmHg (Venturi mask, FiO2 = 0.5) and PaCO2 ≤ 45 mmHg; meeting criteria for weaning; SBT failure Exclusion criteria: age < 18; MV < 48 hrs; tracheotomy; percentage of cuff leak in tidal volume < 15.5%; unable to spontaneously clear secretions from their airway; recent oral, nasal, facial or cranial trauma or surgery; recent gastrointestinal bleeding; severe abdominal distention; lack of co‐operation; COPD, asthma, interstitial lung disease, neuromuscular disease
Interventions	Intervention group (HFNC): flow = 50 L/min; FiO2 = 1.0 then titrated to SpO2 ≥ 92% Control group 1 (NIV): Respironics V60, Philips; FiO2 titrated to SpO2 ≥ 96 %; PEEP initially 4 cm H2O increasing to a maximum of 12 cm H2O; IPAP initially 8 cm H2O increasing to obtain a tidal volume of 6 to 8 mL/kg Control group 2 (standard oxygen therapy): Venturi mask
Outcomes	All outcomes reported: duration of invasive MV Outcomes relevant to this review: none
Starting date	31 May 2017
Contact information	Zujin Luo, xmjg2002@163.com
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