NCT03607357.

Study name	The effect of post‐extubation high‐flow nasal oxygen in patients with acute left heart failure: a clinical multi‐center study
Methods	RCT, parallel‐group design. Multicentre study
Participants	Estimated number of participants: 120 Setting: ICU, China Inclusion criteria: clinical diagnosis of acute left heart failure; invasive MV > 24 hours; passes spontaneous breathing trials; next of kin agrees to sign the informed consent Exclusion criteria: COPD; disturbance of consciousness; bulbar paralysis, dysphagia; facial deformity; terminal tumour; neuromuscular disease
Interventions	Intervention group (HFNC): flow = 30 L/min increasing in 5 L/min increments to tolerance; FiO2 titrated to SpO2 > 95% Control group (NIV): BiPAP; IPAP = 6 to 8 cm H2O; PEEP = 4 cm H2O FiO2 titrated to SpO2 > 95% for both groups
Outcomes	All outcomes measured: reintubation within 48 hours; 28‐day mortality; hospitalisation time; length of ICU stay; blood gas analysis Outcomes relevant to this review: reintubation within 48 hours; 28‐day mortality; hospitalisation time; length of ICU stay; blood gas analysis
Starting date	31 July 2018
Contact information	Zhenglong Ye, zlyenj@126.com. Yuan Ding, 446490001@qq.com
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