NCT04253405.

Study name	Multicentric randomized controlled pilot study comparing high‐flow nasal cannula versus non‐invasive positive pressure ventilation in acute respiratory failure in patients with pulmonary fibrosis (RENOVATE Fibrosis)
Methods	RCT, parallel‐group design. Multicentre study
Participants	Estimated number of participants: 50 Setting: ICU or ED, Brazil Inclusion criteria: age ≥ 18; admitted to ICU or ED with pulmonary fibrosis and AHRF Exclusion criteria: pulmonary fibrosis secondary to progressive massive fibrosis (silicosis), or any other tumour form of fibrosis; significant pulmonary arterial hypertension; pneumothorax or extensive pleural effusion; cardiogenic pulmonary congestion; delirium or non‐co‐operation at the time of randomization; facial abnormalities; uncoercible vomiting or hypersecretion of the airways; use of continuous NIPPV or HFNC for more than 8 hours before randomization; pregnancy; refusal to participate
Interventions	Intervention group (HFNC): Airvo2, Fisher & Paykel Control group (NIV): BiPAP; oronasal or full face mask
Outcomes	All outcomes measured: recruitment feasibility; dyspnoea (Borg scale); respiratory rate; oxygenation; PaCO2 Outcomes relevant to this review: dyspnoea (Borg scale); respiratory rate; oxygenation; PaCO2
Starting date	5 February 2020
Contact information	Leticia Kawano‐Dourado, ldourado@hcor.com.br. Karina Negrelli, knegrelli@hcor.com.br
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