NCT04293991.

Study name	High‐flow nasal cannula versus non‐invasive ventilation in prevention of intubation in immunocompromised patient with acute hypoxemic respiratory failure
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 76 Setting: ICU, Egypt Inclusion criteria: admitted immunocompromised patient to ICU with AHRF; haematological malignancies; post‐bone marrow transplantation Exclusion criteria: need of emergency intubation; patient with deterioration of conscious level with hypoxaemia with FiO2 less than 90% in spite of maximum O2 support; haemodynamic instability with need of vasoconstrictor support
Interventions	Intervention group (HFNC): flow = 60 L/min and titrated downwards to comfort; patient encouraged to have mouth closed Control group (NIV): BiPAP; face mask; IPAP = 8 to 10 cm H2O; PEEP = 5 cm H2O, to maintain a tidal volume of 6‐8 mL/kg FiO2 titrated to SpO2 of ≥ 92% for both groups
Outcomes	All outcomes measured: intubation within 48 hours of admission; 28‐day mortality Outcomes relevant to this review: intubation within 48 hours of admission; 28‐day mortality
Starting date	3rd March 2020
Contact information	Ashraf Elagamy, elagamy_ashraf@yahoo.com. Dalia Elfawy, daliamfawy@yahoo.com
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