Comparison 1. Continuous Infusion vs. Bolus Injection.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Total urine output (cc in 24 hour) excluding Aaser 1997	6	213	Mean Difference (IV, Fixed, 95% CI)	410.16 [220.82, 599.50]
1.2 Total urine output (cc in 24 hour) 7 studies	7	221	Mean Difference (IV, Fixed, 95% CI)	271.01 [93.07, 448.96]
1.3 Duration of Hospitalization (in days)	1	107	Mean Difference (IV, Fixed, 95% CI)	‐3.13 [‐4.06, ‐2.20]
1.4 All Cause Mortality	2	140	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.38, 0.71]
1.5 Cardiac Mortality	1	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.47 [0.33, 0.69]
1.6 Clinically relevant changes in Blood Chemistry Hypokalemia and Hypomagnemesia	3	71	Risk Ratio (M‐H, Fixed, 95% CI)	1.47 [0.52, 4.15]
1.7 Adverse Effects Tinnitus and Hearing Loss	5	218	Risk Ratio (M‐H, Fixed, 95% CI)	0.06 [0.01, 0.44]
1.8 Increase in Serum Creatinine Levels	3	180	Mean Difference (IV, Fixed, 95% CI)	‐0.54 [‐0.57, ‐0.51]
1.9 Total urine output (cc in 24 hour) 5 studies excluding Aaser, Licata,	5	106	Mean Difference (IV, Fixed, 95% CI)	296.38 [‐75.40, 668.16]
1.10 Total urine output (cc in 24 hour) excluding Licata	6	114	Mean Difference (IV, Fixed, 95% CI)	‐67.60 [‐370.21, 235.01]