| Study | Reason for exclusion |
|---|---|
| Beitler 2019 | This study compares 2 groups: control group with values of PEEP set according to PEEP/FIO₂ combination and intervention group with PEEP levels set to achieve transpulmonary pressure of 0 to 6 cmH₂O at end‐expiration. Study included clinical endpoints and was the continuation of a first study (Talmor 2008), which evaluated physiological and clinical endpoints included in the previous review. Exclusion was the result of no difference in PEEP levels between groups |
| Constantin 2019 | This study proposed a personalised ventilatory strategy according to pulmonary morphology, separating the groups into 2: focal ARDS and non‐focal ARDS; study compared those 2 groups with a control group that used low levels of PEEP. In non‐focal ARDS subgroup, recruiting manoeuvres and high levels of PEEP were proposed; when this group was compared with the control group, no difference in PEEP levels occurred during first 72 hours of MV |
| Huh 2009 | This RCT evaluated 2 groups with different modes of PEEP titration: PEEP set according to PEEP/FIO₂ combination (control group) and PEEP titrated until decrease in SpO₂ ≥ 2% (intervention group). Exclusion was the result of no difference in PEEP levels between groups in first 72 hours |
| Khan 2018 | This randomised controlled study evaluated 2 groups with different modes of PEEP titration: low levels of PEEP (control group) and recruiting manoeuvres followed by decremental PEEP titration according to best lung compliance (intervention group). Exclusion was the result of lack of data on ventilatory strategy and values of PEEP during first 7 days in either group |
| Kung 2019 | This RCT assessed 2 groups with different modes of PEEP titration: PEEP/FIO₂ combination (control group) and recruiting manoeuvres followed by decremental PEEP titration according to best lung dynamic compliance (intervention group). Exclusion was the result of no difference in PEEP levels between groups in first 72 hours |
| Pintado 2013 | This pilot RCT assessed 2 groups with different modes of PEEP titration: PEEP/FIO₂ combination (control group) and incremental PEEP titration according to best static lung compliance (intervention group). Exclusion was the result of no difference in PEEP levels between groups in first 72 hours |
| Wang 2019 | This was a physiological study of participants with traumatic ARDS that aimed to explore whether PEEP guided by oesophageal pressure (intervention group) is better than PEEP/FIO₂ combination (control group). Exclusion was the result of outcomes that are physiological (oxygenation index, respiratory mechanics, haemodynamics indices, inflammation mediators) |
FIO₂: fraction of inspired oxygen.
PEEP: positive end‐expiratory pressure.
RCT: randomised controlled trial.
SpO₂: oxygen saturation.