Adamyan 2008.
Study characteristics | ||
Methods |
Study design: RCT Unit of randomisation: No information Total duration of study: No information Run‐in period: No information Intervention time: 90 days Follow‐up: At 30 days and 90 days Setting: No information |
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Participants |
Type of heart failure: End stage of HF N = 145 participants (ivabradine: 70; SC: 75) Mean age: 58 ± 7 years Gender: 109 (75%) male, 36 (25%) female Severity of condition: HFrEF < 35% Inclusion criteria:
Exclusion criteria: No information Withdrawals: No information |
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Interventions |
Intervention: Ivabradine 7.5 mg twice a day Comparison: SC Concomitant medications:
Excluded medications: No information |
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Outcomes |
Outcomes and time points measured in the study: [Day 0, 30, 90]
Conclusion:
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Notes |
Funding for trial: No information Notable conflicts of interest of authors: No information Contact to authors/unpublished data: We contacted KG Adamyan and S Grigoryan via email on 22 November 2018 to ask for funding, country, number of centres, and missing data. The email to KG Adamyan failed, but S Grigoryan answered that she had forwarded the email to the correct email address. Nevertheless, we did not receive an answer. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Insufficient information to base judgement |
Allocation concealment (selection bias) | Unclear risk | Insufficient information to base judgement |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No blinding possible due to comparison with standard care. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Insufficient information to base judgement |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Insufficient information to base judgement |
Selective reporting (reporting bias) | Unclear risk | Insufficient information to base judgement |
Other bias | Unclear risk | Insufficient information to base judgement |