Summary of findings 3. Microcatheter‐assisted trabeculotomy compared with conventional trabeculotomy for primary congenital glaucoma.
| Microcatheter‐assisted trabeculotomy compared with conventional trabeculotomy for primary congenital glaucoma | |||||
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Patient or population: children at or before five years of age with primary congenital glaucoma Setting: university hospitals Intervention: microcatheter‐assisted trabeculotomy Comparison: conventional trabeculotomy | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| Conventional trabeculotomy | Microcatheter‐assisted trabeculotomy | ||||
| Mean IOP 1 year after surgery | The mean IOP ranged across control groups from 11.7 to 12.8. | The mean IOP in the intervention groups was 9.5 to 11.9 and on an average 1.77 lower (95% CI −2.92 to −0.63). | ‐ | 99 eyes (2 studies) | ⊕⊕⊕⊝ moderate1 |
| Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 1 year after surgery | 577 per 1000 | 894 per 1000 (889 to 900) | RR 1.54 (1.20 to 1.97) | 99 eyes (2 studies) | ⊕⊕⊕⊝ moderate1 |
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Adverse outcomes— hyphema Up to 1 year after surgery |
173 per 1000 | 400 per 1000 (67 to 900) | RR 2.25 (1.25 to 4.04) | 102 eyes (2 studies) | ⊕⊕⊕⊝ moderate1 |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; IOP: intraocular pressure; RR: risk ratio | |||||
| GRADE Working Group grades of evidence High certainty: Further research is very unlikely to change our confidence in the estimate of effect. Moderate certainty: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low certainty: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low certainty: We are very uncertain about the estimate. | |||||
1Downgraded one level for imprecision of results due to small sample size.