Table 1.
Participant characteristics in women with preconception SSRI exposure compared to no antidepressant exposure.
| Characteristics | No preconception antidepressant exposure (N=1035) | Preconception SSRI exposure (N=172) | P-value |
|---|---|---|---|
| Age, years | 28.6 ± 4.7 | 29.2 ± 5.1 | 0.13 |
| BMI, kg/m2 | 26.0 ± 6 | 27.6 ± 7 | <0.01 |
| Race, % white | 977 (94) | 169 (98) | 0.03 |
| Education, % with greater than high school | 889 (86) | 151 (88) | 0.52 |
| Income, % ≥$75,000 | 540 (52) | 91 (53) | 0.87 |
| Employed, % | 769 (77) | 113 (67) | <0.01 |
| Physical activity level, % | 0.83 | ||
| Low | 266 (26) | 48 (28) | |
| Moderate | 425 (41) | 68 (40) | |
| High | 343 (33) | 56 (33) | |
| Perceived stress scorea | 0.8 ± 0.5 | 0.9 ± 0.5 | 0.02 |
| Any smoking in past 12 months, % | 120 (12) | 25 (15) | 0.28 |
| Any alcohol intake in past 12 months, % | 58 (32) | 343 (34) | 0.71 |
| THC exposure, % any | 46 (4) | 11 (6) | 0.26 |
| Opioid exposure, % any | 168 (16) | 40 (23) | 0.02 |
| Intercourse frequency during fertile windowb | 3.4 (1.9) | 3.1 (2.1) | 0.58 |
| Intercourse frequency in past 12 months | 0.35 | ||
| ≥1 per week | 816 (82) | 128 (79) | |
| <1 per week | 178 (18) | 34 (21) | |
| Number of prior pregnancy losses, % | 0.84 | ||
| 1 | 696 (67) | 117 (68) | |
| 2 | 339 (33) | 55 (32) | |
| Number of prior live births, % ≥1 | 589 (57) | 103 (60) | 0.47 |
| 0 | 492 (48) | 74 (43) | |
| 1 | 364 (35) | 65 (38) | |
| 2 | 179 (17) | 33 (19) | |
| Time since last pregnancy resolution, weeks (median (IQR)) | 15.7 (8, 37) | 13.9 (7, 39) | 0.83 |
| Last pregnancy resulted in non-live outcome, % yes | 957 (94) | 154 (92) | 0.32 |
| Withdrew from study, % | 117 (11) | 17 (10) | 0.58 |
| Study site, % | 0.36 | ||
| Pennsylvania | 66 (6) | 8 (5) | |
| New York | 68 (7) | 7 (4) | |
| Utah | 839 (81) | 149 (87) | |
| Colorado | 62 (6) | 8 (5) | |
| Randomized to low-dose aspirin in EAGeR trial | 522 (50) | 82 (48) | 0.50 |
Data are mean ± SD or N (%) unless otherwise noted. Non-SSRI antidepressant exposure (n=11) was excluded. THC, tetrahydrocannabinoid.
a
The average during the first cycle of study participation of daily stress measured via a Likert scale: 0=no stress, 1=little stress, 2=moderate stress, and 3=a lot of stress.
b
The average intercourse events for all observed preconception cycles.