Comparison 3. Insulin detemir versus insulin glargine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 All‐cause mortality	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected
3.2 Severe hypoglycaemia	2	763	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.13, 2.63]
3.3 Severe hypoglycaemia (published vs. unpublished data)	2	763	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.13, 2.63]
3.3.1 Published	1	320	Risk Ratio (M‐H, Random, 95% CI)	0.25 [0.07, 0.86]
3.3.2 Unpublished	1	443	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.72, 1.77]
3.4 Hypoglycaemia reported as a serious adverse event	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.14, 9.48]
3.5 Cardiovascular mortality	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.6 Non‐fatal myocardial infarction	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.7 Non‐fatal stroke	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.8 Serious adverse events	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.72 [0.91, 3.28]
3.9 Diabetic ketoacidosis	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.10 Non‐serious adverse events	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.93, 1.09]
3.11 Non‐serious adverse events (published vs. unpublished data)	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.93, 1.09]
3.11.1 Published	1	443	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.97, 1.10]
3.11.2 Unpublished	1	320	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.84, 1.09]
3.12 Withdrawals due to adverse events	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.31, 3.67]
3.13 Any nocturnal hypoglycaemia	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.93, 1.09]
3.13.1 Published	1	320	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.75, 1.17]
3.13.2 Unpublished	1	443	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.94, 1.11]
3.14 Confirmed nocturnal hypoglycaemia (PG < 3.1 mmol/L and no assistance)	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.92, 1.10]
3.14.1 Published	1	320	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.71, 1.16]
3.14.2 Unpublished	1	443	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.93, 1.12]
3.15 Symptomatic nocturnal hypoglycaemia (PG ≥ 3.1 or no PG and no assistance required)	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.81, 1.29]
3.15.1 Published	1	320	Risk Ratio (M‐H, Random, 95% CI)	1.29 [0.78, 2.12]
3.15.2 Unpublished	1	443	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.77, 1.21]
3.16 Severe nocturnal hypoglycaemia	2	763	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.06, 5.12]
3.16.1 Published	1	320	Risk Ratio (M‐H, Random, 95% CI)	0.11 [0.01, 2.02]
3.16.2 Unpublished	1	443	Risk Ratio (M‐H, Random, 95% CI)	1.18 [0.60, 2.32]
3.17 Mild/moderate hypoglycaemia	2	763	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.94, 1.14]
3.17.1 Published	1	320	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.95, 1.26]
3.17.2 Unpublished	1	443	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.96, 1.06]
3.18 HbA1c	2	717	Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.13, 0.12]
3.19 Individuals with HbA1c < 7% without severe hypoglycaemia	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected