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. 2021 Mar 4;2021(3):CD013498. doi: 10.1002/14651858.CD013498.pub2

Comparison 4. Insulin degludec versus insulin detemir.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 All‐cause mortality 2   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.1.1 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.1.2 Children 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.2 Health‐related quality of life 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.2.1 Physical health score 1 454 Mean Difference (IV, Fixed, 95% CI) ‐0.60 [‐1.83, 0.63]
4.2.2 Mental health score 1 454 Mean Difference (IV, Fixed, 95% CI) ‐3.00 [‐4.44, ‐1.56]
4.3 Severe hypoglycaemia 2 802 Risk Ratio (M‐H, Random, 95% CI) 1.17 [0.81, 1.69]
4.3.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 1.01 [0.57, 1.78]
4.3.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 1.30 [0.80, 2.12]
4.4 Hypoglycaemia reported as a serious adverse event 2 802 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.37, 2.32]
4.4.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 0.69 [0.29, 1.69]
4.4.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 2.01 [0.37, 10.84]
4.5 Cardiovascular mortality 2   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.5.1 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.5.2 Children 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.6 Non‐fatal myocardial infarction 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.7 Non‐fatal stroke 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.8 End stage renal disease 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.9 Blindness 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.10 Serious adverse events 2 802 Risk Ratio (M‐H, Random, 95% CI) 1.25 [0.76, 2.05]
4.10.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 1.45 [0.67, 3.17]
4.10.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 1.13 [0.60, 2.15]
4.11 Diabetic ketoacidosis 2   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
4.11.1 Adults 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
4.11.2 Children 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
4.12 Non‐serious adverse events 2 802 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.96, 1.08]
4.12.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.88, 1.11]
4.12.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.97, 1.10]
4.13 Withdrawals due to adverse events 2 802 Risk Ratio (M‐H, Random, 95% CI) 2.32 [0.38, 14.18]
4.13.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 1.51 [0.16, 14.44]
4.13.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 5.03 [0.24, 103.99]
4.14 Nocturnal hypoglycaemia 2 802 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.94, 1.15]
4.14.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 1.00 [0.85, 1.18]
4.14.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 1.07 [0.94, 1.21]
4.15 Mild nocturnal hypoglycaemia 2 802 Risk Ratio (M‐H, Random, 95% CI) 0.97 [0.86, 1.10]
4.15.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.85, 1.16]
4.15.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 0.95 [0.79, 1.15]
4.16 Nocturnal hypoglycaemia (symptomatic) 2 802 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.15, 3.59]
4.16.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 0.38 [0.20, 0.72]
4.16.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 2.01 [0.37, 10.84]
4.17 Nocturnal hypoglycaemia (asymptomatic) 2 802 Risk Ratio (M‐H, Random, 95% CI) 0.91 [0.80, 1.03]
4.17.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 0.93 [0.70, 1.23]
4.17.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 0.90 [0.79, 1.04]
4.18 Severe nocturnal hypoglycaemia 2 802 Risk Ratio (M‐H, Random, 95% CI) 1.12 [0.51, 2.46]
4.18.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 1.21 [0.43, 3.38]
4.18.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 1.01 [0.30, 3.41]
4.19 Mild/moderate hypoglycaemia 2 802 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.99, 1.05]
4.19.1 Adults 1 453 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.96, 1.08]
4.19.2 Children 1 349 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.99, 1.06]
4.20 HbA1c 2 805 Mean Difference (IV, Random, 95% CI) 0.05 [‐0.08, 0.18]
4.20.1 Adults 1 455 Mean Difference (IV, Random, 95% CI) 0.00 [‐0.18, 0.18]
4.20.2 Children 1 350 Mean Difference (IV, Random, 95% CI) 0.11 [‐0.08, 0.30]
4.21 Individuals with HbA1c < 7% without severe hypoglycaemia 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected