Study ID	Review's primary and secondary outcomes	Timing of outcome measurement in study
Bartley 2008	Hypoglycaemia and safety data	At each visit (baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks, 52 weeks, 64 weeks, 76 weeks, 88 weeks, 104 weeks)a
	HbA1c	Baseline, 12 weeks, 24 weeks, 36 weeks, 52 weeks, 64 weeks, 76 weeks, 88 weeks, 104 weeksa
BEGIN Basal‐Bolus Type 1	Hypoglycaemia and safety data	Baseline, every second week during study (main study) (for extension study every 4th week)a
	HbA1c	Baseline, 12 weeks, 16 weeks, 26 weeks
BEGIN Flex T1	Hypoglycaemia and safety	Baseline, every second week during study
	HbA1c	Baseline, 12 weeks, 16 weeks, 26 weeks
BEGIN Young	Hypoglycaemia and safety	Every visit (i.e. every third week during study)
	HbA1c	Baseline, 12 weeks, 16 weeks, 38 weeks, 52 weeks
Bolli 2009	Quality of life	Baseline, 12 weeks, 24 weeks
	HbA1c	Baseline, 8 weeks, 16 weeks, 24 weeks
	Safety	At each visit (number of visits not described)
Chase 2008	Quality of life	Baseline, 2 weeks, 6 weeks, 12 weeks, 18 weeks, 24 weeksa
	HbA1c and hypoglycaemia	During clinical visits at 6 weeks, 12 weeks, 18 weeks, 24 weeks
	Adverse events	Every 1 week of follow‐up
Davies 2014	Quality of life	Baseline, 12 weeks, 26 weeks
	Adverse events and hypoglycaemia	Baseline, 1 week, 2 weeks and thereafter every second week
	HbA1c	Baseline, 12 weeks, 16 weeks, 26 weeks
Fulcher 2005a	Quality of life	Baseline, 14 weeks, 30 weeks
	Adverse events	6 weeks, 12 weeks, 18 weeks, 14 weeks, 30 weeks
	HbA1c	6 weeks, 14 weeks, 22 weeks, 30 weeks
	Hypoglycaemia	6 weeks, 12 weeks, 18 weeks, 14 weeks, 30 weeks
	Economic data	14 weeks, 30 weeks
Heller 2009	Hypoglycaemic and adverse events	Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks, 18 weeks, 24 weeks, 50 weeks, 36 weeks, 44 weeks, 52 weeks
	HbA1c	Baseline, 12 weeks, 24 weeks, 36 weeks, 52 weeks
Home 2005	Quality of life	Baseline, 8 weeks, 20 weeks, 28 weeks
	Hypoglycaemia, adverse events, HbA1c	Baseline, 1 week, 4 weeks, 8 weeks, 12 weeks, 20 weeks, 28 weeks
Kobayashi 2007	Hypoglycaemia, adverse events, HbA1c	Baseline, 48 weeks
Liu 2016	HbA1c	Baseline, 12 weeks, 24 weeks
	Hypoglycaemia, safety	Baseline, 1 week, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 16 weeks, 20 weeks, 24 weeks, 25 weeksa
NCT00595374	Mortality, adverse events	—
NCT00605137	Hypoglycaemia, adverse events	Baseline, 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 14 weeks, 16 weeks, 18 weeks, 20 weeks, 22 weeks, 24 weeks
	HbA1c	Baseline, 4 weeks, 8 weeks, 12 weeks, 16 weeks, 20 weeks, 24 weeks
Pieber 2007	Hypoglycaemia and adverse events	Baseline, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 8 weeks, 14 weeks, 20 weeks, 26 weeks
	HbA1c	Baseline, 20 weeks, 26 weeks
Porcellati 2004	Hypoglycaemia	—
	HbA1c	Not reported, but based on figure 2 in main publication, then every second month (0, 2, 4, 6, 8, 10, 12 months)
PRESCHOOL	Adverse events, hypoglycaemia	Baseline, 1 week, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 16 weeks, 20 weeks, 24 weeks, 26 weeks
	HbA1c	Baseline, 12 weeks, 24 weeks
Ratner 2000	Hypoglycaemia and adverse events	Baseline, 1 week, 4 weeks, 8 weeks, 12 weeks, 20 weeks, 28 weeksa
	Quality of life	Baseline, 8 weeks, 20 weeks, 28 weeksa
	Pharmacoeconomic assessment	Baseline, 1 week, 4 weeks, 8 weeks, 12 weeks, 20 weeks, 28 weeksa
	HbA1c	Baseline, 8 weeks, 20 weeks, 28 weeks
Robertson 2007a	Hypoglycaemia and safety	Baseline, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 10 weeks, 18 weeks, 26 weeks
	HbA1c	Baseline, 18 weeks, 24 weeks
Russell‐Jones 2004	Hypoglycaemia and adverse events	Baseline, 2 weeks, 4 weeks, 9 weeks, 13 weeks, 19 weeks, 26 weeks
	HbA1c	Baseline, 3 months, 6 months
Schober 2002	Hypoglycaemia and adverse events	Baseline, 4 weeks, 16 weeks, 28 weeks
	HbA1c	Baseline, 4 weeks, 16 weeks, 28 weeks
Standl 2004	Quality of life	Baseline, 13 weeks, 26 weeks
	Safety and hypoglycaemia	Baseline, 3 months, 6 months (extension: 9 months, 12 months)
	HbA1c	Baseline, 3 months, 6 months (extension: 9 months, 12 months)
SWITCH 1	Quality of life	Baseline, 32 weeks
	Hypoglycaemia/adverse events	Weekly during study period
	HbA1c	Baseline, 8 weeks, 12 weeks, 16 weeks, 20 weeks, 24 weeks, 28 weeks, 32 weeks
Thalange 2013	Adverse events, hypoglycaemia	Collected during the study
	HbA1c	Baseline, 12 weeks, 24 weeks, 38 weeks, 52 weeks
Urakami 2017	HbA1c and hypoglycaemia	Baseline, 4 weeks, 12 weeks, 24 weeks
Vague 2003a	Hypoglycaemia, safety	Baseline, 2 weeks, 4 weeks, 9 weeks, 13 weeks, 19 weeks, 26 weeks, 27 weeks
	HbA1c	Baseline, 13 weeks, 26 weeks
—: denotes not reported aInformation retrieved from clinical study report. HbA1c: glycosylated haemoglobin A1c.