Outcome measure	Detemir vs NPH	Glargine vs NPH	Detemir vs glargine	Degludec vs detemir	Degludec vs glargine
Severe hypoglycaemia	RR 0.69, 95% CI 0.52 to 0.92a	RR 0.84, 95% CI 0.67 to 1.04	RR 0.59, 95% CI 0.13 to 2.63	RR 1.17, 95% CI 0.81 to 1.69	RR 1.22, 95% CI 0.82 to 1.82
Hypoglycaemia reported as a serious adverse event	RR 0.93, 95% CI 0.51 to 1.71	RR 0.94, 95% CI 0.64 to 1.39	RR 1.16, 95% CI 0.14 to 9.48	RR 0.92, 95% CI 0.37 to 2.32	RR 0.81, 95% CI 0.40 to 1.66
Severe nocturnal hypoglycaemia	RR 0.67, 95% CI 0.39 to 1.17	RR 0.83, 95% CI 0.62 to 1.12	RR 0.55, 95% CI 0.06 to 5.12	RR 1.12, 95% CI 0.51 to 2.46	RR 1.39, 95% CI 0.59 to 3.27
Any nocturnal hypoglycaemia	RR 0.91, 95% CI 0.87 to 0.95a	RR 1.00, 95% CI 0.96 to 1.05	RR 1.01, 95% CI 0.93 to 1.09	No data	RR 0.99, 95% CI 0.91 to 1.07
Confirmed nocturnal hypoglycaemia	No data	No data	RR 1.01, 95% CI 0.92 to 1.10	RR 1.04, 95% CI 0.94 to 1.15	No data
Mild nocturnal hypoglycaemia	RR 0.90, 95% CI 0.85 to 0.96a	RR 0.84, 95% CI 0.66 to 1.07	No data	RR 0.97, 95% CI 0.86 to 1.10 (documented)	RR 0.98, 95% CI 0.90 to 1.07
Symptomatic nocturnal hypoglycaemia	RR 0.88, 95% CI 0.79 to 0.98a	RR 0.93, 95% CI 0.82 to 1.05	RR 1.02, 95% CI 0.81 to 1.29	RR 0.72, 95% CI 0.15 to 3.59	RR 1.22, 95% CI 0.72 to 2.07
Asymptomatic nocturnal hypoglycaemia	No evidence of a difference	Not reported	No data	RR 0.91, 95% CI 0.80 to 1.03	RR 0.84, 95% CI 0.71 to 1.00
Mild/moderate hypoglycaemia	RR 0.97, 95% CI 0.94 to 0.99a	RR 1.02, 95% CI 1.00 to 1.04	RR 1.04, 95% CI 0.94 to 1.14	RR 1.02, 95% CI 0.99 to 1.05	RR 1.02, 95% CI 0.99 to 1.04
HbA1c < 7.0%  without major/severe hypoglycaemia	No data	No data	RR 1.11, 95% CI 0.81 to 1.51	RR 1.09, 95% CI 0.84 to 1.41	RR 0.92, 95% CI 0.78 to 1.10
aFavouring insulin detemir CI: confidence interval; HbA1c: glycosylated haemoglobin A1c; NPH: neutral protamine Hagedorn; RR: risk ratio.